Nigella sativa L. Ranunculaceae Love-in-the-mist, Black Cumin, Nutmeg flower, Roman Coriander. Distribution: SW Asia. Culpeper (1650) writes: ‘Nigella seeds, boyled in oil, and the forehead anointed with it, ease pains in the head, take away leprosie, itch, scurf, and helps scald-heads, inwardly taken they expel worms, they provoke urine and the terms, help difficulty of breathing: the smoke of them (being burned) drives away serpents and venomous beasts.’ The seeds are used as a spice, but as might be expected as a member of the family Ranunculaceae, the buttercups, the plant contains a highly poisonous glycoside, in this case called melanthin. The amount of toxicity present in spices is clearly insufficient to cause problems when used as such.

Proven usage in man as a food flavouring and feed additive in animals for more than 3000 years. Provisional GRAS status in the USA and temporary acceptance in the EU as a food additive. Lack of sufficient formal experimental and clinical toxicity data is the reason for the ‘Provisional’ acceptance. This aspect and extensive information about the composition are extensively reviewed by Burdock G. 2022.

The seeds are used as a spice, but as might be expected as a member of the family Ranunculaceae, the buttercups, the plant contains a highly poisonous glycoside, in this case called melanthin. The amount of toxicity present in spices is clearly insufficient to cause problems when used as such.