The following notes refer to the traditional medicinal uses of the related species Coyledon orbiculata. This is a well-known medicinal plant in South Africa. The fleshy part of the leaf is applied to soften and remove hard corns and warts. The Southern Sotho use a dried leaf as a protective charm for an orphan child and as a plaything. In the Willowmore District, the heated leaf is used as a poultice for boils and other accessible inflammations, earache in particular . Van Wyk et al. (1997) report that a single leaf is eaten as a vermifuge and that the warmed juice can be used as drops for toothache or earache. They also report that the juice has been used to treat epilepsy.

Syn. = Cotyledon orbiculata undulata.