Active principle: (for Euonymus europaea and related species): all parts, especially fruits: evobioside, evomonoside and other cardenolides, evonine and several alkaloids

Class 1b, Highly hazardous; cardiac glycosides inhibit Na+,K+-ATPase, irritation of GI tract, nausea, hallucinations, extensive vomiting, shock, hyperthermia, bloody diarrhoea, liver and kidney disturbance, arrhythmia, strong spasms, coma after 12 h, cardiac arrest