Traditional Herbal Medicine Registration (THMR). The leaves of Aloe Vera and Aloe Ferox contain a yellow/brown latex, just under the skin, and a clear gel which originates from the centre of the leaf. The extracts are believed to have been used since Egyptian times. The latex contains hydroxyanthrone derivatives which have laxative properties and, in moderation, may benefit those with constipation. As with all stimulant laxatives excess use may lead to metabolic disturbances and, with prolonged use, a non-functioning colon and severe constipation unresponsive to laxatives. The gel is of greater value with substantial anecdotal reports supporting its use in the treatment of a range of skin disorders, including eczema and burns. It is unclear whether the alleged benefits arise from the gels ability to dry to a thin film thereby cooling the skin and providing a barrier to troublesome microbes or whether there are active anti-inflammatory compounds within the preparation. In favour of the later explanation are randomised trials, albeit small scale, showing benefits in bowel inflammation (colitis). The claims that aloe vera is beneficial in diabetes have not been substantiated GR Foster November 2018